If you come from Siena, you must drive for Cassia (Statal street 12) in the Rome direction .
After Buonconvento, only few kilometres, you will find on the right the street
for Montalcino.

If you come from Grosseto, you must drive for Siena-Grosseto since Paganico and after, you must continue with direction Sant'Angelo in Colle-Montalcino.

If you come from Autostrada del Sole (A1), you can exit to Chiusi-Chianciano or
Bettolle (better). You must go to Montepulciano and after you travel in the Siena direction,since to Torrenieri, where you find the Montalcino street.